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International regulatory responses have begun reflecting the mounting evidence, with the Danish Medicines Agency acknowledging the findings and the World Health Organizations Advisory Committee on Safety of Medicinal Products recommending in June 2025 that NAION be added as a potential risk in semaglutides Risk Management Plan

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Peptide Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1) Molecular Formula: CHNO Molecular Weight: 1025.182 g/mol PubChem CID: 9941379 CAS Number: 189691-06-3 Source: PubChem PT-141 is provided as a research grade peptide for scientific study in controlled laboratory environments