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While randomized prevention trials are still needed, the consistency and biological coherence of current data support cautious optimism

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Social interaction test (SI) The social interaction apparatus consisted of a transparent acrylic arena divided into three equally sized chambers connected with guillotine doors

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Protein-bound uremic toxins (IS, pCS, PAGln) accumulate exponentially as eGFR declines below 60 mL/min/1.73 m 2 due to saturable OAT1/3-mediated tubular secretion (113, 167), with patients at eGFR 30 exhibiting 510 higher IS than those at eGFR 90reflecting clearance impairment rather than unique pathogenic mechanisms