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The accumulation of ROS beyond glutathione's scavenging capacity

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Since mutants devoid of GSH ( gsh1 ) or with an altered GSH redox ratio ( glr1 ) were susceptible to H 2 O 2 , GSH is a crucial antioxidant found in yeast cells that plays a vital role in protecting against H 2 O 2 damage (Shao et al., 2019

Of note, similarly to combination therapy formulations with insulin, amylin RA needs to exhibit greater stability at pH 7.4 in order to provide the conditions to co-formulate with GLP-1 analogs [33, 41]

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