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In addition, we observed that HIF-1 protein levels accumulate downstream of mTOR in response to GLP-1R signalling, whereas we also demonstrated that depletion of HIF-1 impaired effects on glycolysis and transcriptional regulation of glycolytic genes

Zock JP

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In this review, we first introduce metabolic pathways that enable glutamine to respond to diverse cellular needs and then discuss the metabolic link by which glutamine-derived metabolites may affect cellular metabolic processes, including NEAA synthesis, epigenetic modifications, and hypoxia adaptation

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