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The standard dosing schedule starts with 0.25 mg weekly for the first four weeks, increases to 0.5 mg weekly from weeks five through eight, and then may escalate to 1 mg or 2 mg weekly depending on tolerance and response

In ENDOCAN-1, participants score four specific types of pain every single week: overall pelvic pain, period pain (dysmenorrhoea), pain during sex (dyspareunia), and pelvic pain at other times of the month

Researchers interested in whether those pathways interact use a fixed-ratio preparation so that the exposure is identical across samples rather than assembled by hand each time

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Applied warm, theyre ideal for tired legs and poor circulation