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Within the tumor microenvironment (TME), tumor cells reprogram glucose, lipid, and amino acid metabolism to competitively deplete critical nutrients (e.g., glucose, glutamine, arginine) and accumulate inhibitory metabolites (e.g., lactate), thereby suppressing CD8 + T cell function and proliferation to facilitate immune evasion (Tharp et al., 2024

IV therapy effects and duration vary by individual and treatment type.

Pharmacokinetic studies in humans have found that about 30%-40% of an oral dose of a racemic mixture of R -lipoic acid and S -lipoic acid is absorbed (6, 7)

CA Cancer J Clin

DOX + L-car group Before starting chemotherapy, rats were given L-carnitine (L-car, 250 mg/kg