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For women who choose not to undergo HRT, the results still suggest that semaglutide can support clinically meaningful weight loss of over 10% during menopause

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The oral GLP-1 landscape is newer than most people realise

When HbA 1c was measured in %, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 0.38% [95% CI 0.75% to 0.01%]), 1.0 mg (MD = 0.45% [95% CI 0.60% to 0.31%]) and 0.5 mg (MD = 0.51% [95% CI 0.68% to 0.33%]), respectively (ESM Table 7)

For everyone else paying out of pocket, the new cash-pay pricing offers $199 monthly for the first two months and $349 ongoing