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Noteworthy reductions in TGF--induced pro-fibrotic gene expression and NOX4 expression were observed upon the inhibition of mtROS production (193)

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On the other hand, excessive intake of certain nutrients, such as iron and copper, can increase oxidative stress and disrupt metal homeostasis, leading to tissue damage and impaired detoxification

Furthermore, insulin plays a critical role in the brain and is also involved in the phosphorylation of tau [7, 8], which leads to neurofibrillary tangles, a hallmark of AD-associated neurodegeneration