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PATHOPHYSIOLOGY AND MECHANISMS Migraine is a complex and disabling neurological disorder, more prevalent in women, whose pathophysiology involves neurovascular mechanisms, mitochondrial dysfunction, neurogenic inflammation, and oxidative stress

Specifically, B vitamins aid in the production of enzymes responsible for detoxifying harmful substances, ensuring that the liver can efficiently neutralize toxins and prevent damage

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The inclusion criteria were as follows: the study type must be an RCT

Funding The salary of LB is supported by a National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant (ID: 1172987) and a National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498)