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Semaglutide is FDA-approved for weight management under the brand name Wegovy and is also the active ingredient in Ozempic, which is FDA-approved for diabetes but commonly prescribed off-label for weight loss
Its reduced form (GSH) donates electrons to neutralise reactive oxygen species (ROS) generated during mitochondrial respiration and lipid metabolism, converting to oxidised glutathione (GSSG) in the process
In addition, palbociclib led to a reduction of GPX4 and ferritin levels that likely contributed to increase ferroptosis vulnerability
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Beyond influencing brain signals, semaglutide GLP-1 also slows down the stomachs emptying process, extending the sensation of fullness and minimizing the tendency to overeat or snack between meals
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