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This is a smart precautionary strategy that reduces the impact of potentially stronger side effects at the higher dose

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These can signal gastrointestinal irritation, ulcers, or reduced kidney function

The time-resolved data obtained by single-cell confocal microscopy of green fluorescent protein (GFP) reporters and qPCR of the Nrf2 pathway components complemented with siRNA knock down experiments, is accurately described by the calibrated mathematical model

Since DNA replication stress can also be regulated by the redox status, we then measured ROS, GSSG, and reduced GSH in these cells