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10.4103/1673-5374.320969 99 VukojeviJ.SiroglaviM.KanikK.KraljT.StaniD.KokotA.et al (2018)

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Understanding the Innate Repair Receptor (IRR) The innate repair receptor is a heteromeric receptor complex composed of: Erythropoietin receptor (EPOR) -common receptor (CD131) This receptor is activated in response to: Tissue injury Hypoxia Inflammation Oxidative stress Activation of the IRR triggers a cascade of protective signaling designed to: Limit tissue damage Reduce inflammation Promote cellular survival Support repair rather than scarring ARA-290 was designed specifically to activate this receptor without activating erythropoiesis

GHK-Cu's anti-inflammatory effects flow through its broader gene-expression activity

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