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53 Under the IRAs framework, there is a fundamental incentive distortion between small molecules and biologics: Small Molecules: Subject to price negotiation 9 years after approval

There are medications that mimic its effects, such as semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro, Zepbound)

Zepbound should be discontinued if pregnancy is confirmed

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