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No large-scale Phase III clinical trials have been completed in humans, and long-term safety data in human subjects is lacking

Its mechanism of action remains an active area of investigation, with researchers exploring interactions between this peptide and multiple signaling networks involved in cellular repair and cytoprotection

Glutathione biosynthesis and its inhibition

Considering that curcumin can also cross the BBB, most studies investigating its therapeutic effects in neurodegenerative diseases focus on PD

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