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Open communication with a trial clinician about tolerability is therefore essential
Collectively, these sequences share a conserved metal binding site conforming to a DxHx 10 Hx 2 (H/E) motif in the 5 helix that defines an interfacial site between the two subunits of the dimer, and an additional metal binding site harboring a CxC motif in the 3 helix (Figure 10B)
10.1146/annurev-genet-032918-021921 38 DeoP.DhillonV
Experiments are designed to quantify its effects on collagen I and III synthesis (via qPCR or Western blot), myofibroblast differentiation (by measuring -smooth muscle actin expression), and the critical MMP/TIMP balance
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