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Report suspected side effects to the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

34 AnsariPHannon-FletcherMPFlattPRAbdel-WahabYHA

Increased body weight with obesity affects insulin sensitivity, glucose intolerance, cerebral blood flow, aging progression, and susceptibility to infection, such as with coronavirus disease 2019 (COVID-19) in DM patients

What has changed is not the feasibility of developing drugs without complete biological knowledge, but the expectation that developers be transparent about what is and is not known, and that uncertainty be actively managed rather than minimized (ICH E9 guidance

Neither the Wegovy prescribing information nor the Ozempic prescribing information (which uses the same active ingredient, semaglutide, for diabetes management) includes photosensitivity among their documented adverse effects