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In a study designed to assess whether PGN is a tumor promoter, mice were first given azoxymethane (10 mg/kg injected intraperitoneally), a genotoxic colonic carcinogen that gives rise to colon adenomas or carcinomas, and then PGN (2% in drinking water)

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Using transmission electron microscopy (TEM), we could observe shrunken mitochondria with increased membrane density and reduced mitochondrial cristae on the inner surface of the cyst walls (Fig