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Vitamin C attacks free radicals first, thereby sparing glutathione and helps convert oxidized glutathione back into its stable and active form known as the reduced glutathione

It also has a number of other health benefits and helps to protect the body cells against damage caused by reactive oxygen species

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The response is also known as chronic inflammation

In clinical practice, SGLT2 inhibitors are often initiated first due to their oral administration and broader reimbursement, with GLP-1 receptor agonists subsequently added to address persistent hyperglycemia, excess body weight, or residual albuminuria [84,85]