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The relevance of this finding to humans has not been established, but caution is warranted

H., Chen, K

Skin Tone and Pigmentation Reduction Glutathione inhibits tyrosinase, the enzyme that triggers melanin production, which makes it a clinically studied option for hyperpigmentation and uneven skin tone

The UPR, crucial for innate and adaptive immunity, is activated in this situation, suggesting its role in regulating and maintaining the immune response in vitiligo.42 Another recent study analyzed the role of mitochondrial energy metabolism in melanocytes from vitiligo patients, finding reduced ATP production, increased proton leakage, altered expression of glycolytic enzymes, and hyperactivity of the PGC1 axis

doi: 10.3390/molecules29133051 77 Sanches ContieriLMendes de Souza MesquitaLFerreiraVCMorenoJAPizaniRSForster CarneiroTet al