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Some experts have postulated that GLP-1 receptors could be protective against cytokine-mediated apoptosis (cell death) and may also stimulate neurogenesis (cell life)
Akkari, J
10.1016/j.biochi.2020.04.019 130 RoseS.MelnykS.SavenkaA.HubanksA.ClevesS
In the third study, where iPSCs were generated from PBMCs of 12 different Fabry patients carrying the same mutation in the GLA gene and used to generate cardiomyocytes, reduced enzyme activity, increased Gb3 accumulation and hypertrophy could be observed in comparison to healthy donor-derived iPSC-CMs [79]
Autophagy impairment induces premature senescence in primary human fibroblasts
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