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It has been proposed that this peptide may directly affect metabolism and reduce associated complications independent of its effects on obesity

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BDNF upregulation The most well-documented mechanism of Semax is its ability to upregulate brain-derived neurotrophic factor (BDNF) a protein that plays a central role in neurogenesis, synaptic plasticity, and the formation and maintenance of neural connections

One of the few reports to support this supposition was the measurement of portal venous endotoxin concentrations and culturable bacteria in patients undergoing elective laparotomy [59]

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