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Mouse models allow elegant mechanistic dissection, but the complexity of human MASHespecially in the context of metabolic heterogeneitydemands cautious interpretation

Rybelsus is not FDA approved for weight loss, but a higher-dose oral semaglutide (25 mg) was approved for that purpose in December 2025 under the brand name Wegovy

Mounjaro is the brand name for tirzepatide, a prescription medicine licensed in the United Kingdom for the treatment of type 2 diabetes mellitus and, more recently, for chronic weight management in adults with obesity or overweight with weight-related comorbidities (under the brand name Zepbound)

Drinking at least 8 ounces of water per hour of flight time helps your body process the medication effectively and reduces travel-related discomfort

Principal component analysis (PCA) of the metabolomic data showed a clear separation between NC and DM groups, with the DM + SE group clustering closer to the NC group, indicating metabolic normalization (Figure 4A)