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These appear to be dose-dependent and typically resolve with dose reduction

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We found that these two metabolites in the mevalonate pathway exerted their anti-ferroptotic functions through the same mechanism: accelerating degradation of SQLE to increase intracellular levels of both squalene and coenzyme Q

FIGURE 1 2 Literature search strategy To support the narrative synthesis, a focused literature search was conducted across PubMed, Web of Science, ScienceDirect, and SpringerLink, targeting English-language, peer-reviewed articles published between 2010 and 2025

Seal Tightly : Ensure the lid is tightly sealed to prevent air exposure, which can lead to oxidation