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doi: 10.1021/tx9701687

Notably, NAC significantly reduced oocyte ROS levels and increased the mitochondrial membrane potential in PCOS mice

These data, together with mechanistic work showing that insulin stimulates VEGF and IGF production while glucose primes macrophages for inflammatory cytokine release 394 , suggest that the combination of high glucose and high insulin is more deleterious than hyperglycemia alone

US Centers for Disease Control and Prevention

Moreover, the research showed that the overexpression of fat mass and obesity-associated protein (FTO) suppressed PTC development by downregulating SLC7A11 expression via inducing ferroptosis (59)