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This multidimensional, networked mode of action provides a rationale for precision microecological interventions tailored to specific barrier defects

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Although regulating the MUFA/PUFA ratio by lactate through the SCD1/ASCL4 pathway does affect membrane lipid peroxidation sensitivity, this protective effect against ferroptosis may be more highly dependent on the state of the intracellular antioxidant system (83)