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This stimulation potentially triggers the synthesis and secretion of endogenous growth hormone (GH) in a pulsatile manner

Chemical modification of metformin into sulfenamides and sulfonamides has also improved the cellular accumulation of these compounds in cancer cells, with a subsequent increase in their cytotoxic efficacy

During the clinical application of these drugs, it is imperative to strike a balance between efficacy and risks, and to conduct regular monitoring of blood routine, infection indicators, and liver and kidney functions