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A few authors have proposed that folate may actually worsen the neurologic dysfunction

Phase I Block (Depolarizing Block) Activation of nACh receptors causes membrane depolarization Transient, random muscle fasciculations of varying duration and intensity occur in 94% of patients (Renew, 2026) 5) Continuous membrane depolarization causes inactivation of sodium channels The muscle membrane becomes unresponsive to acetylcholine within 1-2 minutes after i.v

According to the manufacturer, the usual daily recommended amounts of methylcobalamin, vitamin B12 for lactating women should be taken maternally during breastfeeding (see Dosage)