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injected the nonmetabolizable glucose analogue 2-deoxy-D-glucose in the lateral ventricle to establish chronic low-energy metabolism models and reported that chronic suppression of brain energy metabolism, especially a reduction in glucose use, can induce epileptic seizures ( Antiseizure therapy causes changes in glucose metabolism

Patients should also be aware that certain medicationssuch as proton pump inhibitors (PPIs) and metformincan interfere with B12 absorption, though this is less relevant once on injection therapy

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Long-acting agents like Exenatide (once weekly), Liraglutide, Dulaglutide, Semaglutide, and several others have been favored for use based on data from comparative trails