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Discuss all treatment options with your physician before making decisions about weight loss medications

Avoid caffeine and alcohol, which have diuretic effects and can worsen dehydration

Weight loss outcomes were larger than those seen in the STEP trials

Our new analyses provide assurance that the medication, when taken by individuals who are free of significant mental health concerns, does not increase the risk of depression, suicidal thoughts, or suicidal behavior, said lead author Thomas Wadden, a psychologist at the Perelman School of Medicine at the University of Pennsylvania, in a press release

Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article