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Our findings regarding cytotoxicity align with previous reports in the literature, which extensively document the induction of oxidative stress following exposure to PS-MPs ( Not only did PS-MP increased cytotoxicity, oxidative stress, protein carbonylation, and lipid peroxidation, but they affected the entire placental metabolism.The disrupted amino acid levels may indicate disturbances in protein metabolism, while the altered levels of hypoxanthine and formate correlate directly with deficiencies in folate and purinergic metabolism

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