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By upregulating the mitochondrial anti-apoptotic pathway through an increase in AMP-activated protein kinase (AMPK) phosphorylation and an increase in the Bcl-2/Bax ratio (AMPK), modest dosages of withaferin A were found to have a cardioprotective effect in this rat investigation [54]
TabeY, Harada M, Miyamae Y, Mogushi K, Kazuno S, Fujimura T, Matsushita H, Ueno T, Yokomizo T, Miida T, Samudio I, Andreeff M , Konopleva M
Glutathione acts to decrease the production of eumelanin in the skin cells, which is a darker pigment
FOXO3 also prevents pro-apoptotic BAX translocation to the mitochondria, hence protecting cells from apoptosis 100
Kt qu l ln da c ci thin r rt, tr nn trng hng t nhin, ng thi cc khuyt im nh nm, tn nhang cng dn m i
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