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7,8 Postmortem analyses further identified astrocytes as the source of this dysregulation, with increased MAOB-mediated GABA synthesis and reduced ABAT-mediated degradation as key underlying mechanisms (Study 3)

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However, at high concentrations, when RNS levels exceed the capability of its detoxification in the biological system, serious damage to cells may occur [147, 148] due to inhibition of mitochondrial respiratory function by competing with O 2 for interaction with cytochrome oxidase [149] and via nitrative/nitrosative stress [150, 151]

Answer: Side effects are usually mild and short-lived, most often bruising, soreness, or coolness at the IV site

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