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Other side effects include nausea, breast tenderness, and breakthrough menstrual bleeding

Buse, M.D., from the University of North Carolina School of Medicine in Chapel Hill, and colleagues randomly assigned 2,713 adults with inadequately controlled type 2 diabetes receiving metformin with or without SGLT2i with overweight or obesity to receive cagrilintide-semaglutide, semaglutide, cagrilintide, or placebo for 68 weeks

Earlier Phase 2 data also showed up to 24.2% loss at 48 weeks

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So, semaglutide, tirzepatide, and other GLP-1 and GIP analogues are drugs that have demonstrated unmatched effectiveness in the medical treatment of obesity and related potentially fatal diseases and complications