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These metabolites are produced through enzymatic, pseudo-enzymatic, and non-enzymatic reactions of melatonin with ROS and RNS [12,18,29,44,51,52,53]

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Studies show that 81.6% of patients with chronic dermatitis, including CHE, have at least one positive patch test reaction, often revealing overlooked allergens that contribute to persistent symptoms [59]

Wang G, et al

I hope that you can now appreciate the potential benefits of thiamine for improving the symptoms of fibromyalgia and have a better understanding of the potential mechanisms behind how this nutrient works.