Indeed, 17-AAG (Tanespimycin) and 17-DMAG (Alvespimycin), two synthetic derivates of Geldanamycin antibiotic, used as HSP90 inhibitors, improve physiological parameters in bleomycin-induced pulmonary fibrosis mice model 25,26
Cordido F, Pealva A, Dieguez C, Casanueva FF
[1] From this theory, we can propose that stimulating IGF-1 in skin tissue may be a potential effective treatment for regulating skin cell differentiation, improving insulin sensitivity in the skin, reducing keratinocyte proliferation, inhibiting inflammation via stimulation of IL-10 production and up-regulating sebocyte proliferation (via IGF-1 stimulation of 5-Reductase)
Typical daily range: 100300 mcg once daily with gradual titration
Conversely, restoring glutathione can strengthen immune defenses, partly by optimizing T-cell lymphocyte activity and reducing harmful chronic inflammation