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Disproportionality analysis Disproportionality analysis represents a fundamental methodology in pharmacovigilance and drug safety surveillance, designed to identify potential safety signals through the detection of statistical imbalances in adverse drug reaction (ADR) reporting patterns

It also helps lighten dark spots and reduces pigmentation, encouraging an even skin tone

The Short Answer Yes

However, evidence on longer-term effects and side effects remains limited or uncertain, partly due to potential conflicts of interest

For the scope of the article and extensiveness of the field, it is impossible to cover in all its aspects