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After several hours, LPS treatment causes elevated IL-6 levels and hypoglycemia to develop and Ex4 administration blunts this hypoglycemic effect in rats suggesting that the effect of GLP-1 is related to glucose control (247) although the direction goes opposite of what we normally think of as GLP-1-mediated glucose control

Obesity (Silver Spring) 2025;33:15041517

International Journal of Pharmaceutical Compounding

The EMA committee specifically found methodological issues in studies that had claimed a link and concluded there was no causative proof ( [147] ) ( [148] )