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That broad action is probably one of the biggest reasons for its successits not targeting a single neuronal population or process. Most of the GLP-1 molecules cannot cross the bloodbrain barrier directly
Within the ER, hexose-6-phosphate dehydrogenase converts glucose-6-phosphate and NADP + to 6-phosphogluconate and NADPH in a single step, whereas this process in the cytosol requires two separate enzymes (G6PD and PGLS)
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Dose Range: 5001000 mcg daily with gradual titration (~5 mg/week average)
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