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Still, the experience was valuable

A comprehensive clinical assessment is necessary to identify the true underlying cause

Subsequently, Hopkins reported this substance as a dipeptide containing glutamate and cysteine, and he named it glutathione (10), which is a tripeptide consisting of glutamate, cysteine, and glycine (11, 12)

This enzyme is, however, highly expressed in human liver, testes, and kidney (7)

Abbreviations GLP1RAs Glucagon-like peptide 1 receptor agonists PCOS Polycystic ovary syndrome RCT Randomized controlled trial WMD Weighted mean difference SMD Standardized mean difference RR Risks ratio CI Confidence interval SD Standard deviations IR Insulin resistance GI Gastrointestinal GnRH Gonadotropin-releasing hormone LIRA Liraglutuide EXE Exenatide MET Metformin CC Clomifene citrate NM Not mentioned BID Twice a day QD Once a day COMBI Combined group MF Menstrual frequency PR Pregnancy rate IVF In vitro fertilization TBF Total body fat BMI Body mass index WC Waist circumference HOMA-IR Homeostasis model assessment-insulin resistance TT Total testosterone fT Free testosterone FAI Free androgen index DHEAS Dehydroepiandrosterone sulphate SHBG Sex hormone binding globulin OGTT Oral glucose tolerance test BP Blood pressure ART Assisted reproductive technology GDM Gestational diabetes mellitus FDA Food and Drug Administration EMA European Medicines Agency HPO axis Hypothalamus pituitary ovary axis CRP C-reactive protein IL-18 Interleukin 18 TNF- Tumor necrosis factor IL-6 Interleukin 6 Authors contributions LZ came up with the subject