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[DOI] [Google Scholar] 12.Trinity J.D., Lee J.F., Pahnke M.D., Beck K.C., Coyle E.F

doi: 10.18632/aging.102038 38 DeligneCCasulliSPigenetABougaultCCampillo-GimenezLNourissatGet al

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism

TB-500 (the Thymosin Beta-4 fragment) sequesters actin, drives cell migration and stem cell mobilisation, and reduces apoptosis and inflammation

This finding again supports the hypothesis that combination therapies will yield more synergistic mechanisms to help with the skin-lightening effect, but more studies are warranted to validate the synergistic effects of glutathione further [15]