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While MPNST remains a challenging malignancy, several promising advances are underway: MEK Inhibitors in NF1-Associated MPNST Given the dysregulation of the RAS/RAF/MEK pathway in NF1-related tumors, MEK inhibitors like selumetinib have shown efficacy in benign plexiform neurofibromas

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The major proglucagon fragment: an abundant islet protein and secretory product