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Olson, Ph.D., University of California, Davis The prefrontal cortex (PFC) plays a critical role in regulating reward and controlling drug-seeking behavior

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In general, although with exceptions, activated endothelial cells act as the initial stimulus, causing the subsequent recruitment of leukocytes which release a host of pro-fibrotic cytokines like IL-6 and TGF-1, which act on local fibroblasts to create a fibrogenic environment, causing the transition from inactive into aberrantly activated SMA expressing myofibroblasts ( ACTA2 and THY1 (encoding for SMA and CD90, respectively), also contribute to the progression of fibrosis (50)

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No entanto, para que esses efeitos sejam percebidos, necessrio um perodo de uso contnuo e algumas variveis influenciam esse processo

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