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Common injection site reactions are characterized by itching and burning at the site of administration with or without thickening of the skin (welting)
These effects are linked to an increase in -cell mass
In the -cell, PC1/3 is up-regulated, resulting in increased processing of proglucagon to GLP-1 while DPP-4 is down-regulated in order to reduce degradation and enhance local intact GLP-1 concentrations
Best Pract Res Clin Endocrinol Metab 2009;23:479-86.ArticlePubMed 75
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