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Furthermore, E2 increases GLP-1 secretion, and GLP-1 levels decrease in response to ovariectomy, an effect which can be rescued by E2 administration (72)

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Ipamorelin's research value largely derives from acting more narrowly within this system activating the GH-release arm of ghrelin signaling with substantially less spillover into the appetite, cortisol, and prolactin pathways that broader ghrelin-receptor activation, or older secretagogues like GHRP-6, tend to produce