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No Observed Desensitization: If extensive data indicates no signs of diminishing returns or receptor desensitization, researchers might experiment with slightly longer on-cycles in future studies, always with careful monitoring

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AM: Vitamin C & VItamin E, SPF, polypodium 480 mg Midday: Sunscreen reapplication, polypodium 480 mg PM: Melatonin 2-4 mg taken nightly The combination of choice will be determined by your physician at The Melasma Clinic

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Roderburg C, Krieg S, Krieg A, Vaghiri S, Mohr R, Konrad M, et al