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Keywords: Pernicious anemia, Vitamin B12, Neuropathy, Myelopathy, Parietal cells, Intrinsic factor, Autoimmune, Hyperpigmentation Background Vitamin B12 deficiency is a common global health concern that, if left untreated, can result in a range of hematological and neurological complications

It also participates in the action of serotonin

Vitamin B12 should be supplemented in vegetarians who do not get adequate amounts of B12 from diet or patients consuming a low calorie/low protein diet

Medications: acid-reflux drugs (PPIs) and some diabetes medications (such as metformin) can interfere with B12 absorption