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Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis
Endocrine (2016) 51(2):32332.10.1007/s12020-015-0667-x 29 LuNSunHYuJWangXLiuDZhaoLet alGlucagon-like peptide-1 receptor agonist liraglutide has anabolic bone effects in ovariectomized rats without diabetes
BBS is a very rare genetic ciliopathy with multisystem manifestations, commonly including early-onset obesity and hyperphagia
A 104-week carcinogenicity study was conducted in male and female Sprague Dawley rats at doses of 0.075, 0.25 and 0.75 mg/kg/day liraglutide administered by bolus subcutaneous injection with exposures 0.5-, 2- and 8-times the human exposure, respectively, resulting from the MRHD based on plasma AUC comparison
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