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10.1152/physrev.00026.2013 142 ZuoZ.JingK.WuH.WangS.YeL.LiZ.et al (2020)

In the absence of stomach and gastric acid, the damaging effects of cysteamine (400 mg/kg s.c., sacrifice 24 hours thereafter), so far thought to be an acid related duodenal ulcerogen, and the cytoprotective effects of NaBPC157 (10 g or 10 ng/kg i.p.) were further challenged in comparison with reference agents (cimetidine (50), ranitidine (10), omeprazole (10), bromocriptine (10) and atropine (10) (values given in mg/kg i.p., 1 hour before cysteamine)) known also to be cytoprotective

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2012) and that our ability to explore this experimentally is restricted by the limited metabolic capability and poor relevance to humans in vivo of many currently available in vitro toxicological models (Park et al