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When the standard error of all individual data points in a group collected randomly was significantly smaller than the average value, the corresponding sample size was deemed appropriate and reliable

Journal of the American Academy of Dermatology Volume 17, Issue 1, July 1987, Pages 97-101

The answer depends upon the health goals, medical conditions, and willingness to commit to a program, not instead of diet and exercise, but as a supplementary aid

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Reverse-phase HPLC (C18 column, acetonitrile/TFA gradient) establishes chromatographic purity with UV 220 nm detection, minimum threshold of 98%, individual impurities quantified below 0.5%