Molecular dynamics simulations of GLRX and complexes Using the crystal structure of GLRX (PDB ID: 4RQR, Uniprot ID: P35754), we constructed models of GLRX wild type and mutants (C83S, C8S, and C79S) as well as the GLRX dimers for molecular dynamics (MD) simulations, using Protein Preparation Wizard (Pymol, Schrdinger, Inc.) and the relaxation strategy in our prior work 52
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Inhibiting tyrosinase enzymes whitens the skin by stopping the production of eumelanin and increasing the production of pheomelanin
Response rates at week 68 were 86.4% for at least 5% loss, 69.1% for at least 10%, and 50.5% for at least 15%, compared with 31.5%, 12.0% and 4.9% respectively on placebo